Nicholas Isherwood has sung in the world’s leading festivals (Salzburg, Aix, Festival d’Automne, Avignon, Almeida, Biennale di Venezia, Holland Festival, Munich Biennale, Wien Modern, Händel Festivals in Göttingen and Halle, Tanglewood, Ravinia, etc.) and opera houses (Royal Opera House, Berlin, Frankfurt, Stuttgart, Amsterdam, Lyon, Châtelet, Théatre des Champs Elysées, Rome, Torino, Genova, La Fenice, La Scala, etc.), working with conductors such as Joel Cohen, William Christie, Peter Eötvös, Gabriele Ferro, Nicholas McGegan, Paul McCreesh, Zubin Mehta, Kent Nagano, Helmuth Rilling, David Robertson, Gennadi Rozhdestvensky and Arturo Tamayo.

Isherwood has worked closely with composers such as Sylvano Bussotti, Elliott Carter, George Crumb. Hans Werner Henze, Mauricio Kagel, György Kurtág, Steve Lacy, Olivier Messiaen, Giacinto Scelsi and Iannis Xenakis.